| 杨玲娟，宋蒙蒙，狄留庆，丁康.天然黄酮类化合物对芳香烃受体的调控作用研究进展[J].南京中医药大学学报(社会科学版),2021,37(6):958-964. |
| 天然黄酮类化合物对芳香烃受体的调控作用研究进展 |
| Recent Progress of Natural Flavonoids as Ligand on Aryl Hydrocarbon Receptor |
| |
| DOI： |
| 中文关键词: 关键词：黄酮 芳香烃受体 配体 |
| 英文关键词: flavonoids aryl hydrocarbon receptor ligands |
| 基金项目: |
|
| 摘要点击次数: 438 |
| 全文下载次数: 916 |
| 中文摘要: |
| 黄酮类成分广泛存在于植物、中草药中，具有多种药理学活性，近年来的研究表明，它可以通过调控多种信号通路发挥其抗炎、抗氧化、化学预防等作用。笔者聚焦在药物代谢、免疫调节、化学预防中具有重要作用的芳香烃受体，在系统综述芳香烃受体功能及调控模式基础上，总结了不同黄酮类化合物对芳香烃受体的激动或拮抗作用，并对常见黄酮成分通过芳香烃受体发挥其抗肿瘤、抗溃疡性结肠炎、抗特异性皮炎的独特作用机制进行了介绍，并展望了黄酮类化合物在上述疾病治疗中潜在前景和局限性。 |
| 英文摘要: |
| Flavonoids are widely existed in plants and herbs， which have a variety of pharmacological activities. Recent studies have shown that they can exert anti-inflammatory， antioxidant， and chemopreventive effects by regulating various signaling pathways. In this paper， we focused on the aryl hydrocarbon receptor， which plays an important role in drug metabolism， immunomodulation， and chemoprevention. After a systematic review of the functions and regulation modes of aryl hydrocarbon receptor， we summarized the agonistic or antagonistic effects of different flavonoids on aryl hydrocarbon receptor and elaborated their anti-tumor， anti-ulcerative colitis， and anti-atopic dermatitis effects by activating aryl hydrocarbon receptor through unique mechanisms. Furthermore， the potential prospects and limitations of flavonoids in the treatment of the above diseases were also presented. |
|
查看全文
查看/发表评论 下载PDF阅读器 |
| 关闭 |
