| 连紫宇，朱磊，刘亚军，胡静怡，程成，沈洪.溃疡性结肠炎脾气虚证患者代谢特征研究[J].南京中医药大学学报(社会科学版),2021,37(6):830-836. |
| 溃疡性结肠炎脾气虚证患者代谢特征研究 |
| Metabolic Characteristics of Spleen-Qi Deficiency Syndrome in Ulcerative Colitis |
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| DOI： |
| 中文关键词: 关键词:溃疡性结肠炎 脾气虚 代谢组学 |
| 英文关键词: ulcerative colitis spleen-qi deficiency metabolomics |
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| 中文摘要: |
| 目的 基于非靶标代谢组学探索溃疡性结肠炎（UC）脾气虚证的生物学基础。方法 采用液相色谱质谱联用方法对UC脾气虚证和湿热证患者血清进行代谢组学分析。结果 UC脾气虚证存在脂质代谢紊乱，与UC湿热证患者比较，UC脾气虚证血清中1-油酰基甘油磷酸胆碱、溶血磷脂、鞘氨醇、N-棕榈酰磷酸乙醇胺、棕榈酰肉碱、O-花生四烯酰缩水甘油等代谢产物丰度降低，2-亚油酰甘油丰度升高。ROC曲线结果显示，O-花生四烯酰缩水甘油、棕榈酰胺、2-亚油酰甘油可能是诊断UC脾气虚证的潜在生物标志物。结论 代谢组学方法有望揭示UC中医证候的生物学本质，为UC中医辨证提供一定客观依据。 |
| 英文摘要: |
| OBJECTIVE To explore the biological basis of spleen-qi deficiency syndrome of ulcerative colitis based on non-target metabolomics. METHODS The UC patients with spleen-qi deficiency syndrome and damp-heat syndrome were analyzed by metabolomics by LC-MS. RESULTS There were lipid metabolism disorders in UC patients with spleen-qi deficiency. Compared with UC patients with damp-heat， the average abundance of 1-linoleoylglycerophosphocholine，lysophospholipid，sphingosine， N-palmitoyl-phosphoethanolamine， palmitoylcarnitine and O-arachidonoyl glycidol decreased in the UC patients with spleen-qi deficiency， while the average abundance of 2-linoleoyl glycerol increased. ROC curve showed that O-arachidonoyl glycidol， palmitic amide and 2-linoleoyl glycerol may be potential biomarkers of spleen-qi deficiency syndrome in UC. CONCLUSION Metabolomics is expected to reveal the biological nature of TCM syndromes in UC. |
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