| 何溶溶，吕翔，周婧，马宏跃，严燕青，王恒斌，狄留庆，段金廒.雄黄的安全性评价和配伍减毒研究[J].南京中医药大学学报(社会科学版),2018,34(6):645-648. |
| 雄黄的安全性评价和配伍减毒研究 |
| Evaluation on Realgar Safety and Reducing Toxicity |
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| DOI： |
| 中文关键词: 关键词：雄黄 砷 六神丸 配伍减毒 |
| 英文关键词: realgar Arsenic Liushen Wan compatibility to reduce toxicity |
| 基金项目: |
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| 摘要点击次数: 731 |
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| 中文摘要: |
| 雄黄是经典中成药的常见组成药物，因含有硫化砷类成分，其安全性备受关注。介绍了近年国内外对砷存在形式、毒性分子机制基础上，结合含雄黄制剂的临床不良反应报道，探讨了雄黄慢性暴露对实验动物的安全性和减毒研究。并以经典名方六神丸为例，表明方剂配伍对雄黄的减毒效果。提示雄黄制剂在临床合理剂量、用药时间和组方配伍情况下，存在一定安全性。 |
| 英文摘要: |
| Realgar is a common component of classical Chinese medicine preparation， which has attracted much attention due to high content of arsenic sulfide. This reviewed the research on the species， toxicity and molecular mechanism of arsenic in recent years. The clinical adverse effects of realgar-containing preparations and the safety of realgar on chronic exposure to experimental animals were analyzed. In particular， the classic Chinese medicine Liushen Wan compatibility reduced realgar-induced toxicity. That illustrated that the Chinese medicine preparations containing realgar clinically used at low dose and reasonable medication time， have certain drug safety. |
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