| 周婧，何溶溶，蒋洁君，吕翔，段金廒*，马宏跃*.中药配伍减毒研究思路与方法——以蟾酥、牛黄为例[J].南京中医药大学学报(社会科学版),2018,34(4):330-333. |
| 中药配伍减毒研究思路与方法——以蟾酥、牛黄为例 |
| Approaches to Investigate the Compatibility for Reducing Toxicity Using a Case of Bezoar and Toad Venom |
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| DOI： |
| 中文关键词: 蟾酥 牛黄 配伍减毒 研究思路 |
| 英文关键词: toad venom bezoar compatibility detoxification research ideas |
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| 中文摘要: |
| 配伍减毒是中医遣方用药特色优势，通过合理剂量与组方控制，调其偏性，制其毒性，而用于临床，被医家所推崇。本文总结了中药配伍减毒研究的思路与方法，特别是以牛黄和蟾酥为例，在中医理论与实践、减毒效应、化学物质、组/成分间体内/外相互作用以及减毒机理等层面，探讨了其配伍减毒的科学内涵。以期为该领域研究的持续深入和拓展提供经验参考及借鉴。< |
| 英文摘要: |
| Combining herbs is a characteristic advantage of traditional Chinese medicines (TCMs)， done for many thousands of years， and is an important way to reduce the side effects or toxicity caused by TCMs. Here， we introduced the different approaches to investigate the compatibility for the reducing toxicity， using a case of our studies on the compatibility between bezoar and toad venom. These approaches includes mining Chinese medicine theory and clinic data， toxicological evaluation in vivo and in vitro， analysis of chemical constituents， and pharmacokinetic interaction of components， and use of molecular biology or -omics techniques. They could be crucial ways in the development of modern TCMs with better safety that will reinforce advancement to this field. |
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