| 方六一1，石健1，唐春花1，狄红杰2*，刘超2.金芪玉泉方治疗气阴两虚夹瘀型糖尿病肾病的临床研究[J].南京中医药大学学报(社会科学版),2018,34(1):54-57. |
| 金芪玉泉方治疗气阴两虚夹瘀型糖尿病肾病的临床研究 |
| Clinical Study on the Effect of Jinqi Yuquan Formula in the Treatment of Diabetic Nephropathy of Qi and yin Deficiency Combined with Blood Stasis Type |
| |
| DOI： |
| 中文关键词: 糖尿病肾病 金芪玉泉方 足细胞标志蛋白 |
| 英文关键词: diabetic nephropathy Jinqi Yuquan Formula podocalyxin |
| 基金项目: |
|
| 摘要点击次数: 1501 |
| 全文下载次数: 1450 |
| 中文摘要: |
| 目的 研究金芪玉泉方治疗气阴两虚夹瘀型糖尿病肾病(DN)的疗效及其可能的机制。方法 82例辨证为气阴两虚夹瘀型糖尿病肾病患者随机分为治疗组、对照组各41例，均给予控制饮食、适量运动、降糖、降压等基础治疗，治疗组在此基础上加用金芪玉泉方，治疗周期为12周。比较2组治疗前后血糖、血脂谱、血压、肾功能、尿蛋白、血清胱抑素C（CysC）、尿足细胞标志蛋白（PCX）的变化。结果 2组患者治疗前后血糖、血脂、血压无明显变化；治疗组有效率60.97%，对照组有效率29.26%，2组比较差异有统计学意义（P<0.01）；治疗组治疗后的尿白蛋白排泄率（UAER）、24 h尿蛋白定量、估算肾小球滤过率（eGFR）、CysC、PCX较治疗前显著改善（P<0.01），组间比较治疗组优于对照组（P<0.01）。结论 金芪玉泉方能通过保护足细胞功能显著减少气阴两虚夹瘀型糖尿病肾病患者的尿蛋白，改善肾脏功能。 |
| 英文摘要: |
| OBJECTIVE To study the therapeutic effect and the possible mechanism of Jinqi Yuquan Formula(JQYQF) in the treatment of diabetic nephropathy of qi and yin deficiency combined with blood stasis type. METHODS 82 DN patients were randomly divided into the treatment group and the control group， 41 cases in each group. Both groups were given the basic treatments such as diet controlling， regular exercising， hypoglycemic and depressurization. On the basis of the basic treatments， the treatment group was also given JQYQF for 12 weeks continuously. Parameters changes of blood glucose， blood lipid spectrum， blood pressure， renal function， urine protein， serum cystatin C (CysC) and podocalyxin (PCX) in both groups were compared before and after treatment. RESULTS Blood glucose， blood lipid and blood pressure in both groups had no significant changes before and after the treatment. The effective rate was 60.97% in the treatment group and 29.26% in the control group， and the difference between the two groups was statistically significant (P<0.01). Albumin excretion rate (UAER)， 24h urine protein quantitative， estimated glomerular filtration rate (eGFR)， CysC and PCX in the treatment group were significantly improved than those of the pre-treatment (P<0.01)， and those of the treatment groups than the control group (P<0.01). CONCLUSIONS Jinqi Yuquan formula can improve the kidney function by protecting podocyte function and reducing urine protein in diabetic nephropathy patients of qi and yin deficiency combined with blood stasis type. |
|
查看全文
查看/发表评论 下载PDF阅读器 |
| 关闭 |
