| 乔宏志1，2，张蕾1，2，孙娟1，狄留庆1，2*.中药功效物质与靶向治疗策略[J].南京中医药大学学报(社会科学版),2018,34(1):25-29. |
| 中药功效物质与靶向治疗策略 |
| Functional Substance of Chinese Medicine and Targeted Therapy Strategies |
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| DOI： |
| 中文关键词: 中药功效物质 有效成分 引经理论 配伍规律 体内分布 靶向给药 作用机制 |
| 英文关键词: functional substance of Chinese medicine effective components the theory of guiding medicinals compatibility law in vivo distribution targeted drug delivery mechanism of action |
| 基金项目: |
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| 摘要点击次数: 1946 |
| 全文下载次数: 1997 |
| 中文摘要: |
| 中医药与靶向治疗分属两个不同的学科体系，二者既有差别，又有多重联系和潜在的融合空间。这主要体现在二者理论体系的相通性，作用目的的相向性和实践手段的互补性上。中药功效物质的靶向治疗可以从两个角度理解。一方面，很多来源于中药的活性成分存在成药性问题，可通过现代靶向技术制备靶向制剂，以实现增效、减毒的目的；另一方面，在中医药思维下，很多中药功效成分能赋予药物或制剂良好的定向作用，引导他们更多地分布于某些特定区域，发挥靶向治疗的效果。将从上述两个角度综述近年来相关研究进展，以便于理解和发现二者的内在联系和潜在开发价值，促进中医药与制剂学科的融合发展。< |
| 英文摘要: |
| Chinese medicine and targeted therapy belong to two different disciplinary systems. They have both differences and multiple connections and potential for integration. This is mainly reflected in the interconnectedness of the theoretical system， the syntropy of the purpose and the complementarity of the practical means. Targeted treatment of functional substance of Chinese medicine can be understood from two perspectives. On the one hand， many active ingredients derived from Chinese medicine have difficulties in druggability， which can be solved using the modern targeted technology for enhancing the efficacy and reducing the side effects. On the other hand， under the guiding thought of Chinese medicine， many functional substances of Chinese medicine endow drugs or preparations orientation to the specific regions， leading to the improved therapeutic effect. In this review， we summarize the research progress in recent years from the above two aspects in order to understand and discover the intrinsic relationship between them and the potential value of development， which will promote the integration development of Chinese medicine and pharmaceutics. |
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