| 孔雪云1，2，陈琦1，2，吴祥1，2，卞慧敏1，2*，李育3*.中西药联用相互作用研究进展[J].南京中医药大学学报(社会科学版),2018,34(1):5-11. |
| 中西药联用相互作用研究进展 |
| The Research Progress of Interaction Between Chinese and Western Medicine Combination |
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| DOI： |
| 中文关键词: 中西药联用 药代动力学 药酶 药效 不良反应 |
| 英文关键词: combined use of Chinese medicine and western medicine pharmacokinetics drug enzyme efficacy adverse reaction |
| 基金项目: |
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| 摘要点击次数: 1560 |
| 全文下载次数: 2007 |
| 中文摘要: |
| 临床中西药联用日渐普遍，但联合用药后药物相互作用引起的药效改变及不良反应逐渐引起重视。该文从药物吸收、分布、代谢、排泄4个方面，阐述中西药联用时的相互作用。其中，中药的酸碱性、胃肠蠕动和胃排空时间变化、螯合物、络合物、沉淀物形成等影响西药的吸收；中药可改变西药主要活性成分在体内的分布情况；亦可通过作用于肝微粒体酶和非微粒体酶影响西药代谢；通过胆汁与肾脏影响西药排泄；通过P-糖蛋白改变西药的体内转运过程。全文从药代动力学过程说明中西药联合用药的利弊，为临床指导中西药联合用药提供依据。< |
| 英文摘要: |
| The compatibility of Chinese medicine and western medicine is becoming more and more common， but the changes in efficacy and adverse reactions of drug interaction caused by drug interaction has attracted more and more attentions. This article mainly expounds the interaction between Chinese medicine and western medicine in four aspects: absorption， distribution， metabolism and excretion of drugs. Among them， Chinese medicine can affect western medicine absorption by changing the gastrointestinal pH， gastrointestinal motility and gastric emptying time changes， the chelate complexes， and the precipitate formation; it can change the distribution of the main active ingredients in western medicine; it can change liver microsomal enzyme and non-microsomal enzyme to affect western medicine metabolism， the western medicine excretion through the bile and kidney， and western medicine transport process in vivo by P-glycoprotein. The article explains the pros and cons of Chinese medicine and western medicine from the pharmacokinetic process， which provides the basis for the clinical guidance for the combination therapy of Chinese medicine and western medicine. |
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