| 李锦，赵晓莉.一测多评法在消癥胶囊质量控制中的应用[J].南京中医药大学学报(社会科学版),2016,32(5):498-500. |
| 一测多评法在消癥胶囊质量控制中的应用 |
| Application of Quantitative Analysis Multi-Components by Single Marker in Xiaozheng capsule Quality Control |
| 投稿时间：2016-06-16 修订日期：2016-08-15 |
| DOI： |
| 中文关键词: 一测多评 消癥胶囊 相对校正因子 蒽醌类成分 |
| 英文关键词: quantitative analysis multi-components by single marker Xiaozheng capsule related correction factor anthraquinones |
| 基金项目: |
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| 摘要点击次数: 903 |
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| 中文摘要: |
| 目的 建立一测多评法测定消癥胶囊中5种大黄蒽醌类成分的含量。方法 选择大黄素为内参物，建立芦荟大黄素、大黄酸、大黄酚、大黄素甲醚与大黄素的相对校正因子（fk/s），并计算含量，实现一测多评；同时与外标测定法的结果进行对比，以验证一测多评法可行性。结果 在一定的线性范围内，3批消癥胶囊中5种大黄蒽醌类成分所得fk/s计算值与实测值间无显著差异。结论 一测多评法快速、准确，可用于消癥胶囊中大黄蒽醌类成分的质量评价。 |
| 英文摘要: |
| OBJECTIVE To establish a method of quantitative analysis on multi-components by single marker (QAMS) to determine 5 kinds of anthraquinones in Xiaozheng capsule. METHODS Using emodin as internal referring substance，to establish the relative correction factor (fk/s) of Aloe Emodin， rhein， chrysophanol， physcion to emodin and determine these contents. At the same time， an external standard method was established to determine the amounts of 5 kinds of anthraquinones， then compared with the QAMS method. RESULTS The two methods did not show significant difference in assay results according to the data in a certain linear range. CONCLUSION The QAMS method is feasible and credible， and can be used to determine and control the 5 kinds of anthraquinones in Xiaozheng capsule. |
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