| 杨文国，王瑞，刘圣金，吴德康，喻斌，房方，杨江.矿物药青礞石干预COPD大鼠模型的多层数据分析[J].南京中医药大学学报(社会科学版),2016,32(5):470-474. |
| 矿物药青礞石干预COPD大鼠模型的多层数据分析 |
| Multi-Layer Analysis of Chloriti Lapis on Rats Model with COPD |
| 投稿时间：2016-01-20 修订日期：2016-06-27 |
| DOI： |
| 中文关键词: 青礞石 典型相关 主成分 线性多层统计模型 |
| 英文关键词: Chloriti Lapis anonical correlation analysis principal component analysis multiple linear statistical models |
| 基金项目: |
|
| 摘要点击次数: 1159 |
| 全文下载次数: 832 |
| 中文摘要: |
| 目的 分析矿物药青礞石治疗慢性阻塞性肺疾病（COPD）大鼠的疗效。方法 建立COPD大鼠模型，结合青礞石临床应用的方法及剂量，分别给予青礞石粉高剂量、低剂量，水煎液高剂量、低剂量，药渣高剂量、低剂量加以治疗，检测大鼠肺组织、血清中炎症因子的含量。运用典型相关分析、主成分分析、线性多层统计模型评价相关指标。结果 水煎液高剂量组效果最好，粉末高剂量组次之，渣高剂量组第三。结论 青礞石能有效降低COPD模型大鼠血清及肺组织中炎症因子的水平，通过典型相关分析、主成分分析、线性多层数据模型可区分不同处理方法的疗效差异。 |
| 英文摘要: |
| OBJECTIVE To study the curative effects of Chloriti Lapis on rats with chronic obstructive pulmonary diseases(COPD). METHODS Rats models of COPD were established and were given the powder， decoction and residues of Chloriti Lapis of both high dosage and low dosage respectively based on its clinical application methods and dosage. Inflammatory factor content in rats lung tissue and blood serum was tested and relative indexes were evaluated through canonical correlation analysis， principal component analysis and multiple linear statistical models. RESULTS The high dosage group of decoction reached the best result， with the high dosage group of powder being the second and the high dosage group of residues being the third. CONCULSION Chloriti Lapis is effective in reducing inflammatory factors of both blood serum and lung tissue of rats models with COPD. The curative effect differences due to processing methods can be detected by canonical correlation analysis， principal component analysis and multiple linear statistical models. |
|
查看全文
查看/发表评论 下载PDF阅读器 |
| 关闭 |
