| 何伟明，刘不悔，高坤，周栋，盛梅笑，张露，江燕，李正红，孙伟.中医药防治肾纤维化的研究现状及实践[J].南京中医药大学学报(社会科学版),2018,34(2):112-117. |
| 中医药防治肾纤维化的研究现状及实践 |
| Research Progress of Chinese Medicine in the Treatment of Renal Fibrosis |
| 投稿时间：2018-02-01 |
| DOI： |
| 中文关键词: 肾间质纤维化 中医药 单味中药 中药复方制剂 |
| 英文关键词: renal interstitial fibrosis Chinese medicine single Chinese medicine Chinese medicine compound preparation |
| 基金项目: |
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| 摘要点击次数: 1467 |
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| 中文摘要: |
| 肾纤维化是各种慢性肾脏病进展至终末期肾病的病理基础，可危及生命。其发病机制较为复杂，由多种细胞因子和信号通路共同参与。目前尚无有效治疗药物。近年来基于肾纤维化的中医理论及其分子机制，通过随机多中心临床研究以及体内外基础研究，证实多种中药及其有效成分有延缓肾纤维化的疗效，并明确了作用靶点。继续寻找有效的延缓肾纤维化的中药，证实其疗效，明确作用机制尤为重要。 |
| 英文摘要: |
| Renal fibrosis is the pathological basis of the progression of various chronic renal diseases to end-stage renal disease， which is life-threatening. Its pathogenesis is complex and is involved in a variety of cytokines and signaling pathways， and there is no effective therapeutic drug until now. In recent years， on the basis of TCM theory of renal fibrosis and its molecular mechanism， through randomized multicenter clinical study and basic research in vitro and in vivo， our hospital confirmed that a variety of Chinese herbs and their effective components have the effect of delaying renal fibrosis， and we have identified their action target. In a word， we should continue to find effective Chinese medicine that can postpone renal fibrosis， to confirm their curative effect， especially to clear their action mechanism. |
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