| 刘睿,段金廒,李友宾,戴俊,彭蕴茹.水牛角主要药效学评价及解热活性物质基础研究[J].南京中医药大学学报(社会科学版),2007,23(5):297-301. |
| 水牛角主要药效学评价及解热活性物质基础研究 |
| Pharmacodynamics research of water buffalo horn and the basic study of water baffulo horn antipyretic active compound |
| 投稿时间：2007-06-23 修订日期：2007-07-17 |
| DOI： |
| 中文关键词: 水牛角 解热 镇静 促凝血 活性物质基础 |
| 英文关键词: baffulo horn pyretilysis conscious-sedation blood clotting substantial basic |
| 基金项目:国家中医药管理局基金项目（国中医药科2004ZX04-2）;江苏省高校“青蓝工程”科技创新团队建设项目资助（2006年） |
| 刘睿 段金廒 李友宾 戴俊 彭蕴茹 |
| [1]江苏大学药学院,江苏镇江212013 [2]南京中医药大学,江苏南京210046 [3]江苏省中医药研究院。江苏南京210028,江苏南京210046 |
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| 中文摘要: |
| 目的对水牛角的解热、镇静、促凝血等生物活性进行了评价研究，并针对其解热活性的物质基础开展了初步研究。方法采用皮下酵母致热法、光电管法、毛细管法评价了水牛角粉、热提液和冷浸液的解热、镇静、促凝血作用；采用凝胶柱层析法将水牛角热提液按分子量分为大、中、小3个部位。并以皮下酵母致热法评价了各部位的解热作用。结果水牛角粉、水牛角热提液和冷浸液均可降低酵母致热大鼠体温、降低小鼠自发活动次数、缩短小鼠凝血时间，其中热提液的作用强于冷浸液样品；水牛角热提液的大分子量和小分子量部位均能降低酵母致热大鼠体温，中分子量部位作用不明显。结论水牛角粉、水牛角热提液均具有明显的解热、镇静、促凝血作用，冷浸液解热作用较弱；水牛角解热作用的物质基础源于大分子和小分子部位的共同贡献。 |
| 英文摘要: |
| To study the effect of pyretilysis, conscious-sedation, and blood clotting of water buffalo horn, to search the substantial basic of baffulo born. METHOD Pyretolysis experiment, spontaneous movement experiment and blood clotting experiment were used to investigate the bioactivity of water baffulo horn powder, heating water-pheresis and colding water-pheresis. Column chromatography was used to isolate the water baffulo horn heating water-pheresis into three fractions, which were investigated the antipyretic effects. RESULT The experiments showed that water baffulo horn powder, heating water-pberesis and colding water-pberesis, could reduce the times of spontaneous movement, shorten the time of blood clotting time, and reduce the temperature of febrile rat, and the effect of heating water-pheresis was better than colding water-pheresis. The fractions of high-molecular and low-molecular could reduce the temperature of febrile rat, the effect of mid-molecular was inconspicuous. CONCLUSION Water baffulo horn had the effect on pyretolysis, sedation and blood clotting. The fractions of high-molecular and low-molecular had the effects on pyretolysis. |
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